Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor

The Huisgen cycloaddition of azides and alkynes, accelerated by target biomolecules, termed “in situ click chemistry,” has been successfully exploited to discover highly potent enzyme inhibitors. We have previously reported a specific Serratia marcescens chitinase B (SmChiB)-templated syn-triazole i...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Hirose, Tomoyasu, Maita, Nobuo, Gouda, Hiroaki, Koseki, Jun, Yamamoto, Tsuyoshi, Sugawara, Akihiro, Nakano, Hirofumi, Hirono, Shuichi, Shiomi, Kazuro, Watanabe, Takeshi, Taniguchi, Hisaaki, Sharpless, K. Barry, Ōmura, Satoshi, Sunazuka, Toshiaki
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2013
الموضوعات:
Physical Sciences
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791779/
https://ncbi.nlm.nih.gov/pubmed/24043811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315049110
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