Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid

5-Nor stemmadenine alkaloids, isolated from the genus Tabernaemontana, display a range of bioactivity. 16-Hydroxy-16,22-dihydroapparicine, the active component of an extract from the Tabernaemontana sp. (dichotoma, elegans, and divaricate), exhibited potent antimalarial activity, representing the fi...

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Bibliografiske detaljer
Udgivet i:J Nat Med
Main Authors: Noguchi, Yoshihiko, Hirose, Tomoyasu, Ishiyama, Aki, Iwatsuki, Masato, Otoguro, Kazuhiko, Sunazuka, Toshiaki, Ōmura, Satoshi
Format: Artigo
Sprog:Inglês
Udgivet: Springer Japan 2016
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935745/
https://ncbi.nlm.nih.gov/pubmed/27324906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11418-016-1012-2
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