Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity

This Letter describes the synthesis and structure–activity-relationships (SAR) of isoform-selective PLD inhibitors. By virtue of the installation of alternative halogenated piperidinyl benzimidazolone privileged structures, in combination with a key (S)-methyl group, novel PLD inhibitors with low nM...

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Bibliographische Detailangaben
Hauptverfasser: Lewis, Jana A., Scott, Sarah A., Lavieri, Robert, Buck, Jason R., Selvy, Paige E., Stoops, Sydney L., Armstrong, Michelle D., Brown, H. Alex, Lindsley, Craig W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791604/
https://ncbi.nlm.nih.gov/pubmed/19268584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.02.057
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