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Mechanism of amyloid β−protein dimerization determined using single−molecule AFM force spectroscopy
Aβ42 and Aβ40 are the two primary alloforms of human amyloid β−protein (Aβ). The two additional C−terminal residues of Aβ42 result in elevated neurotoxicity compared with Aβ40, but the molecular mechanism underlying this effect remains unclear. Here, we used single−molecule force microscopy to chara...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791449/ https://ncbi.nlm.nih.gov/pubmed/24096987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02880 |
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