Mechanisms of Beat-to-Beat Regulation of Cardiac Pacemaker Cell Function by Ca(2+) Cycling Dynamics

Whether intracellular Ca(2+) cycling dynamics regulate cardiac pacemaker cell function on a beat-to-beat basis remains unknown. Here we show that under physiological conditions, application of low concentrations of caffeine (2–4 mM) to isolated single rabbit sinoatrial node cells acutely reduces the...

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Detalles Bibliográficos
Main Authors: Yaniv, Yael, Stern, Michael D., Lakatta, Edward G., Maltsev, Victor A.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2013
Assuntos:
Cell Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791306/
https://ncbi.nlm.nih.gov/pubmed/24094396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.08.024
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