Age at Onset in Two Common Neurodegenerative Diseases Is Genetically Controlled

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%–60% were found in both the AD and PD data sets. For PD, signi...

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Hauptverfasser: Li, Yi-Ju, Scott, William K., Hedges, Dale J., Zhang, Fengyu, Gaskell, P. Craig, Nance, Martha A., Watts, Ray L., Hubble, Jean P., Koller, William C., Pahwa, Rajesh, Stern, Matthew B., Hiner, Bradley C., Jankovic, Joseph, Allen, Jr., Fred H., Goetz, Christopher G., Mastaglia, Frank, Stajich, Jeffrey M., Gibson, Rachel A., Middleton, Lefkos T., Saunders, Ann M., Scott, Burton L., Small, Gary W., Nicodemus, Kristin K., Reed, Allison D., Schmechel, Donald E., Welsh-Bohmer, Kathleen A., Conneally, P. Michael, Roses, Allen D., Gilbert, John R., Vance, Jeffery M., Haines, Jonathan L., Pericak-Vance, Margaret A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Human Genetics 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC379130/
https://ncbi.nlm.nih.gov/pubmed/11875758
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