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Cyclic N-Terminal Loop of Amylin Forms Non Amyloid Fibers
We report for the first time, to our knowledge, that the N-terminal loop (N_loop) of amylin (islet amyloid polypeptide (IAPP) residues 1–8) forms extremely long and stable non-β-sheet fibers in solution under the same conditions in which human amylin (hIAPP) forms amyloid fibers. This observation ap...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791296/ https://ncbi.nlm.nih.gov/pubmed/24094407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.08.026 |
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