A “Clickable” MTX Reagent as a Practical Tool for Profiling Small-Molecule–Intracellular Target Interactions via MASPIT

We present a scalable synthesis of a versatile MTX reagent with an azide ligation handle that allows rapid γ-selective conjugation to yield MTX fusion compounds (MFCs) appropriate for MASPIT, a three-hybrid system that enables the identification of mammalian cytosolic proteins that interact with a s...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Risseeuw, Martijn D P, De Clercq, Dries J H, Lievens, Sam, Hillaert, Ulrik, Sinnaeve, Davy, Van den Broeck, Freya, Martins, José C, Tavernier, Jan, Van Calenbergh, Serge
Format: Artigo
Sprog:Inglês
Udgivet: WILEY-VCH Verlag 2013
Fag:
Full Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790973/
https://ncbi.nlm.nih.gov/pubmed/23341183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200493
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker