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Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy due to Pulmonary Arterial Hypertension

BACKGROUND: Right ventricular dysfunction (RVD) is the most frequent cause of death in patients with pulmonary arterial hypertension. Whereas abnormal energy substrate utilization has been implicated in the development of chronic left heart failure, data describing such metabolic remodeling in RVD r...

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Detalhes bibliográficos
Main Authors: Gomez-Arroyo, Jose, Mizuno, Shiro, Szczepanek, Karol, Van Tassell, Benjamin, Natarajan, Ramesh, dos Remedios, Cristobal G., Drake, Jennifer I., Farkas, Laszlo, Kraskauskas, Donatas, Wijesinghe, Dayanjan S., Chalfant, Charles E., Bigbee, John, Abbate, Antonio, Lesnefsky, Edward J., Bogaard, Harm J., Voelkel, Norbert F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790960/
https://ncbi.nlm.nih.gov/pubmed/23152488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.111.966127
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