Ovariectomy expands murine short-term hemopoietic stem cell function through T cell expressed CD40L and Wnt10B

Estrogen deficiency expands hemopoietic stem and progenitor cells (HSPCs) and mature blood lineages, but the involved mechanism and the affected HSPC populations are mostly unknown. Here we show that ovariectomy (ovx) expands short-term HSPCs (ST-HSPCs) and improves blood cell engraftment and host s...

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Detalhes bibliográficos
Main Authors: Li, Jau-Yi, Adams, Jonathan, Calvi, Laura M., Lane, Timothy F., Weitzmann, M. Neale, Pacifici, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790505/
https://ncbi.nlm.nih.gov/pubmed/23954891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-487801
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