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Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF(+) T cells and Th17 cells
Estrogen deficiency causes a gut microbiome–dependent expansion of BM Th17 cells and TNF-α–producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF stimulate RANKL expression and activity, causing bone loss. However, the origin of BM Th17 cells and TNF(+) T cells is unknown. He...
Gespeichert in:
| Veröffentlicht in: | J Clin Invest |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Clinical Investigation
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7880410/ https://ncbi.nlm.nih.gov/pubmed/33586672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143137 |
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