Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF(+) T cells and Th17 cells

Estrogen deficiency causes a gut microbiome–dependent expansion of BM Th17 cells and TNF-α–producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF stimulate RANKL expression and activity, causing bone loss. However, the origin of BM Th17 cells and TNF(+) T cells is unknown. He...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Yu, Mingcan, Pal, Subhashis, Paterson, Cameron W., Li, Jau-Yi, Tyagi, Abdul Malik, Adams, Jonathan, Coopersmith, Craig M., Weitzmann, M. Neale, Pacifici, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880410/
https://ncbi.nlm.nih.gov/pubmed/33586672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143137
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