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ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon
The cytosolic pathogen sensor RIG-I is activated by RNAs with exposed 5′-triphosphate (5′-ppp) and terminal double-stranded structures, such as those that are generated during viral infection. RIG-I has been shown to translocate on dsRNA in an ATP-dependent manner. However, the precise role of the A...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
European Molecular Biology Organization
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3790048/ https://ncbi.nlm.nih.gov/pubmed/23846310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.102 |
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