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Structural and Functional Properties of the Membranotropic HIV-1 Glycoprotein gp41 Loop Region Are Modulated by Its Intrinsic Hydrophobic Core

The gp41 disulfide loop region switches from a soluble state to a membrane-bound state during the human immunodeficiency virus type 1 (HIV-1) envelope-mediated membrane fusion process. The loop possesses a hydrophobic core at the center of the region with an unusual basic residue (Lys-601). Furtherm...

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Библиографические подробности
Главные авторы: Qiu, Jiayin, Ashkenazi, Avraham, Liu, Shuwen, Shai, Yechiel
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790013/
https://ncbi.nlm.nih.gov/pubmed/23960077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.496646
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