FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

The p21-activated kinases (PAKs) are immediate downstream effectors of the Rac/Cdc42 small G-proteins and implicated in promoting tumorigenesis in various types of cancer including breast and lung carcinomas. Recent studies have established a requirement for the PAKs in the pathogenesis of Neurofibr...

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Bibliographische Detailangaben
Hauptverfasser: Licciulli, Silvia, Maksimoska, Jasna, Zhou, Chun, Troutman, Scott, Kota, Smitha, Liu, Qin, Duron, Sergio, Campbell, David, Chernoff, Jonathan, Field, Jeffrey, Marmorstein, Ronen, Kissil, Joseph L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790009/
https://ncbi.nlm.nih.gov/pubmed/23960073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510933
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