Human Mitochondrial Chaperone (mtHSP70) and Cysteine Desulfurase (NFS1) Bind Preferentially to the Disordered Conformation, Whereas Co-chaperone (HSC20) Binds to the Structured Conformation of the Iron-Sulfur Cluster Scaffold Protein (ISCU)

Human ISCU is the scaffold protein for mitochondrial iron-sulfur (Fe-S) cluster biogenesis and transfer. NMR spectra have revealed that ISCU populates two conformational states; that is, a more structured state (S) and a partially disordered state (D). We identified two single amino acid substitutio...

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Autori principali: Cai, Kai, Frederick, Ronnie O., Kim, Jin Hae, Reinen, Nichole M., Tonelli, Marco, Markley, John L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789972/
https://ncbi.nlm.nih.gov/pubmed/23940031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482042
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