Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly

Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation. FXN deficiency is associated with Friedreich ataxia, a neurodegenerative disease. We have used a combination of isothermal titration calorimetry and multinuclear NMR spe...

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Gepubliceerd in:J Inorg Biochem
Hoofdauteurs: Cai, Kai, Frederick, Ronnie O., Tonelli, Marco, Markley, John L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5951399/
https://ncbi.nlm.nih.gov/pubmed/29576242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2018.03.007
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