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Programmable DNA-binding Small Molecules

Aberrant gene expression is responsible for a myriad of human diseases from infectious diseases to cancer. Precise regulation of these genes via specific interactions with the DNA double helix could pave the way for novel therapeutics. Pyrrole-imidazole polyamides are small molecules capable of bind...

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Detalhes bibliográficos
Main Authors: Blackledge, Meghan S., Melander, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789866/
https://ncbi.nlm.nih.gov/pubmed/23665141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.023
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