Completion of a Programmable DNA-Binding Small Molecule Library

Hairpin pyrrole-imidazole (Py-Im) polyamides are programmable oligomers that bind the DNA minor groove in a sequence-specific manner with affinities comparable to those of natural DNA-binding proteins. These cell-permeable small molecules have been shown to enter the nuclei of live cells and downreg...

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Hlavní autoři: Hsu, Carey F., Phillips, John W., Trauger, John W., Farkas, Michelle E., Belitsky, Jason M., Heckel, Alexander, Olenyuk, Bogdan Z., Puckett, James W., Wang, Clay C. C., Dervan, Peter B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151752/
https://ncbi.nlm.nih.gov/pubmed/18596841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2007.03.041
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