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Practical Considerations Regarding the Use of Genotype and Pedigree Data to Model Relatedness in the Context of Genome-Wide Association Studies

Genome-wide association studies of complex traits often are complicated by relatedness among individuals. Ignoring or inappropriately accounting for relatedness often results in inflated type I error rates. Either genotype or pedigree data can be used to estimate relatedness for use in mixed-models...

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Main Authors: Cheng, Riyan, Parker, Clarissa C., Abney, Mark, Palmer, Abraham A.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789811/
https://ncbi.nlm.nih.gov/pubmed/23979941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.113.007948
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