Herpes Simplex Virus Type 1 Single Strand DNA Binding Protein and Helicase/Primase Complex Disable Cellular ATR Signaling

Herpes Simplex Virus type 1 (HSV-1) has evolved to disable the cellular DNA damage response kinase, ATR. We have previously shown that HSV-1-infected cells are unable to phosphorylate the ATR substrate Chk1, even under conditions in which replication forks are stalled. Here we report that the HSV-1...

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Detalhes bibliográficos
Main Authors: Mohni, Kareem N., Smith, Samantha, Dee, Alexander R., Schumacher, April J., Weller, Sandra K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789782/
https://ncbi.nlm.nih.gov/pubmed/24098119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003652
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