The Heme Oxygenase-1 Inducer THI-56 Negatively Regulates iNOS Expression and HMGB1 Release in LPS-Activated RAW 264.7 Cells and CLP-Induced Septic Mice

The nuclear DNA binding protein high mobility group box 1 (HMGB1) has recently been suggested to act as a late mediator of septic shock. The effect of ((S)-6,7-dihydroxy-1-(4-hydroxynaphthylmethyl)-1,2,3,4-tetrahydroisoquinoline alkaloid, also known as THI-56, in an experimental model of sepsis was...

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Detalhes bibliográficos
Main Authors: Park, Eun Jung, Jang, Hwa Jin, Tsoyi, Konstantin, Kim, Young Min, Park, Sang Won, Kim, Hye Jung, Lee, Jae Heun, Chang, Ki Churl
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789711/
https://ncbi.nlm.nih.gov/pubmed/24098466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076293
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