Ethyl Pyruvate Induces Heme Oxygenase-1 Through p38 Mitogen-Activated Protein Kinase Activation by Depletion of Glutathione in RAW 264.7 Cells and Improves Survival in Septic Animals

Aims: We investigated the molecular mechanism by which ethyl pyruvate (EP) induces heme oxygenase-1 (HO-1) in RAW 264.7 cells and its effect on survival rate in cecal ligation and puncture (CLP)-induced wild-type (WT) and HO-1 knockout (HO-1(−/−)) septic mice. Results: EP induced HO-1 in a dose- and...

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Main Authors: Jang, Hwa Jin, Kim, Young Min, Tsoyi, Konstantin, Park, Eun Jung, Lee, Young Soo, Kim, Hye Jung, Lee, Jae Heun, Joe, Yeonsoo, Chung, Hun Taeg, Chang, Ki Churl
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392619/
https://ncbi.nlm.nih.gov/pubmed/22369644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.3994
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