Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

BACKGROUND AND PURPOSE: Recently, metformin, a well-known anti-diabetic drug, has been shown to possess anti-inflammatory activities. This study investigated the effect of metformin on the expression of pro-inflammatory cytokines including high mobility group box 1 (HMGB1) in lipopolysaccharide (LPS...

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Detalhes bibliográficos
Main Authors: Tsoyi, Konstantin, Jang, Hwa Jin, Nizamutdinova, Irina Tsoy, Kim, Young Min, Lee, Young Soo, Kim, Hye Jung, Seo, Han Geuk, Lee, Jae Heun, Chang, Ki Churl
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057288/
https://ncbi.nlm.nih.gov/pubmed/21091653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01126.x
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