P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells

6-Hydroxydopamine (6-OHDA) is known to contribute to neuronal death in Parkinson's disease. In this study, we found that the preincubation of SH-SY5Y cells for 24 h with 20 μM notoginsenoside R2 (NGR2), which is a newly isolated notoginsenoside from Panax notoginseng, showed neuroprotective eff...

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Detalhes bibliográficos
Main Authors: Meng, Xiang-Bao, Sun, Gui-Bo, Wang, Min, Sun, Jing, Qin, Meng, Sun, Xiao-Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789498/
https://ncbi.nlm.nih.gov/pubmed/24159358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/971712
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