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Toward detection of DNA-bound proteins using solid-state nanopores: insights from computer simulations

Through all-atom molecular dynamics simulations, we explore the use of nanopores in thin synthetic membranes for detection and identification of DNA binding proteins. Reproducing the setup of a typical experiment, we simulate electric field-driven transport of DNA-bound proteins through nanopores sm...

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Détails bibliographiques
Auteurs principaux: Comer, Jeffrey, Ho, Anthony, Aksimentiev, Aleksei
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789251/
https://ncbi.nlm.nih.gov/pubmed/23147918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elps.201200164
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