A novel selective small-molecule PI3K inhibitor is effective against human multiple myeloma in vitro and in vivo

Developing effective therapies against multiple myeloma (MM) is an unresolved challenge. Phosphatidylinositol-3-kinase (PI3K) activation may be associated with tumor progression and drug resistance, and inhibiting PI3K can induce apoptosis in MM cells. Thus, targeting of PI3K is predicted to increas...

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Hlavní autoři: Glauer, J, Pletz, N, Schön, M, Schneider, P, Liu, N, Ziegelbauer, K, Emmert, S, Wulf, G G, Schön, M P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789203/
https://ncbi.nlm.nih.gov/pubmed/24013662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.37
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