An APOBEC Cytidine Deaminase Mutagenesis Pattern is Widespread in Human Cancers

Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may induce mutation clusters in human tumors. We show here that throughout cancer genomes APOBEC mutagenesis is pervasive and corr...

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Detalhes bibliográficos
Main Authors: Roberts, Steven A., Lawrence, Michael S., Klimczak, Leszek J., Grimm, Sara A., Fargo, David, Stojanov, Petar, Kiezun, Adam, Kryukov, Gregory V., Carter, Scott L., Saksena, Gordon, Harris, Shawn, Shah, Ruchir R., Resnick, Michael A., Getz, Gad, Gordenin, Dmitry A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789062/
https://ncbi.nlm.nih.gov/pubmed/23852170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2702
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