Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies

Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals. In Escherichia coli, the Ada response involves expression of four genes: ada, alkA, alkB,...

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Detalhes bibliográficos
Main Authors: Mielecki, Damian, Saumaa, Signe, Wrzesiński, Michał, Maciejewska, Agnieszka M., Żuchniewicz, Karolina, Sikora, Anna, Piwowarski, Jan, Nieminuszczy, Jadwiga, Kivisaar, Maia, Grzesiuk, Elżbieta
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788762/
https://ncbi.nlm.nih.gov/pubmed/24098441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076198
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