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Unlinked memory helper responses promote long-lasting humoral alloimmunity

Essential help for long-lived alloantibody responses is theoretically provided only by CD4 T cells that recognise target alloantigen, processed and presented by the allospecific B cell. We demonstrate that in an alloresponse to multiple MHC disparities, cognate help for class-switched alloantibody m...

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Detalhes bibliográficos
Main Authors: Conlon, Thomas M, Cole, Jennifer L, Motallebzadeh, Reza, Harper, Inês, Callaghan, Chris J, Bolton, Eleanor M, Bradley, J Andrew, Saeb-Parsy, Kourosh, Pettigrew, Gavin J
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788591/
https://ncbi.nlm.nih.gov/pubmed/23162131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202257
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