Creatine Kinase-Overexpression Improves Myocardial Energetics, Contractile Dysfunction and Survival in Murine Doxorubicin Cardiotoxicity

Doxorubicin (DOX) is a commonly used life-saving antineoplastic agent that also causes dose-dependent cardiotoxicity. Because ATP is absolutely required to sustain normal cardiac contractile function and because impaired ATP synthesis through creatine kinase (CK), the primary myocardial energy reser...

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Autores principales: Gupta, Ashish, Rohlfsen, Cory, Leppo, Michelle K., Chacko, Vadappuram P., Wang, Yibin, Steenbergen, Charles, Weiss, Robert G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3788056/
https://ncbi.nlm.nih.gov/pubmed/24098344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074675
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