Computational De Novo Design and Characterization of a Protein that Selectively Binds a Highly Hyperpolarizable Abiological Chromophore

This work reports the first example of a single-chain protein computationally designed to contain four α-helical segments and fold to form a 4-helix bundle encapsulating a supramolecular abiological chromophore that possesses exceptional nonlinear optical properties. The 109-residue protein designat...

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Hlavní autoři: Fry, H. Christopher, Lehmann, Andreas, Sinks, Louise E., Asselberghs, Inge, Tronin, Andrey, Krishnan, Venkata, Blasie, J. Kent, Clays, Koen, DeGrado, William F., Saven, Jeffrey G., Therien, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787832/
https://ncbi.nlm.nih.gov/pubmed/23931685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4067404
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