De Novo Design of a Single Chain Diphenylporphyrin Metalloprotein

We describe the computational design of a single-chain four-helix bundle that noncovalently self-assembles with fully synthetic non-natural porphyrin cofactors. With this strategy, both the electronic structure of the cofactor as well as its protein environment may be varied to explore and modulate...

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Main Authors: Bender, Gretchen M., Lehmann, Andreas, Zou, Hongling, Cheng, Hong, Fry, H. Christopher, Engel, Don, Therien, Michael J., Blasie, J. Kent, Roder, Heinrich, Saven, Jeffrey G., DeGrado, William F.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542652/
https://ncbi.nlm.nih.gov/pubmed/17691729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja071199j
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