Synthetic Chondramide A Analogues Stabilize Filamentous Actin and Block Invasion by Toxoplasma gondii

[Image: see text] Apicomplexan parasites such as Toxoplasma gondii rely on actin-based motility to cross biological barriers and invade host cells. Key structural and biochemical differences in host and parasite actins make this an attractive target for small-molecule inhibitors. Here we took advant...

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Bibliographische Detailangaben
Hauptverfasser: Ma, Christopher I., Diraviyam, Karthikeyan, Maier, Martin E., Sept, David, Sibley, L. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society and American Society of Pharmacognosy 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787807/
https://ncbi.nlm.nih.gov/pubmed/24020843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np400196w
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