Asparaginyl endopeptidase cleaves TDP-43 in brain

TAR DNA-binding protein 43 (TDP-43) is a nuclear protein involved in RNA splicing and a major protein component in ubiquitin-positive, tau-negative inclusions of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Under disease conditions TDP-43 redistributes to the cyt...

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Main Authors: Herskowitz, Jeremy H., Gozal, Yair M., Duong, Duc M., Dammer, Eric B., Gearing, Marla, Ye, Keqiang, Lah, James J., Peng, Junmin, Levey, Allan I., Seyfried, Nicholas T.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787696/
https://ncbi.nlm.nih.gov/pubmed/22718532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201200006
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