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Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin
Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neuronal axon guidance and other processes. Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates the Ras homolog Rap through an ill-defined no...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3787391/ https://ncbi.nlm.nih.gov/pubmed/24137545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01279 |
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