Combining TRAIL with PI3 Kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling

TRAIL has been shown to induce apoptosis in cancer cells, but in some cases they fail to respond to this ligand. We explored the ability of representative phosphatidylinositol-3-kinase (PI3 Kinase)/mTOR and HSP90 inhibitors to overcome TRAIL resistance by increasing apoptosis in colorectal cancer mo...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Saturno, Grazia, Valenti, Melanie, De Haven Brandon, Alexis, Thomas, George V., Eccles, Suzanne, Clarke, Paul A., Workman, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787150/
https://ncbi.nlm.nih.gov/pubmed/23852390
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker