The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1 via Nuclear Factor Erythroid-2-Related Factor 2

Aims: We asked whether the neuroprotective effect of cholinergic microglial stimulation during an ischemic event acts via a mechanism involving the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or the expression of its target cytoprotective gene, heme oxygenase-1 (HO-1). Speci...

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Autores principales: Parada, Esther, Egea, Javier, Buendia, Izaskun, Negredo, Pilar, Cunha, Ana C., Cardoso, Silvia, Soares, Miguel P., López, Manuela G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2013
Materias:
Original Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785807/
https://ncbi.nlm.nih.gov/pubmed/23311871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4671
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