Leptin Induces IL-6 Expression through OBRl Receptor Signaling Pathway in Human Synovial Fibroblasts

BACKGROUND: Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response. Leptin is abundantly expressed in osteoarthritis (OA) cartilage and synovium. However, the relationship between leptin and inte...

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Detalhes bibliográficos
Main Authors: Yang, Wei-Hung, Liu, Shan-Chi, Tsai, Chun-Hao, Fong, Yi-Chin, Wang, Shoou-Jyi, Chang, Yung-Sen, Tang, Chih-Hsin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785513/
https://ncbi.nlm.nih.gov/pubmed/24086566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075551
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