Leptin Induces IL-6 Expression through OBRl Receptor Signaling Pathway in Human Synovial Fibroblasts

BACKGROUND: Leptin, an adipocyte-secreted hormone that centrally regulates weight control, may exert proinflammatory effects in the joint, depending on the immune response. Leptin is abundantly expressed in osteoarthritis (OA) cartilage and synovium. However, the relationship between leptin and inte...

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Autori principali: Yang, Wei-Hung, Liu, Shan-Chi, Tsai, Chun-Hao, Fong, Yi-Chin, Wang, Shoou-Jyi, Chang, Yung-Sen, Tang, Chih-Hsin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785513/
https://ncbi.nlm.nih.gov/pubmed/24086566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075551
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