Antitumor Activity of NVP-BKM120–A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells

PURPOSE: The aim of this study was to show preclinical efficacy and clinical development potential of NVP-BKM120, a selective pan class I phosphatidylinositol-3 kinase (PI3K) inhibitor in human glioblastoma (GBM) cells in vitro and in vivo. EXPERIMENTAL DESIGN: The effect of NVP-BKM120 on cellular g...

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Hlavní autoři: Koul, Dimpy, Fu, Jun, Shen, Ruijun, LaFortune, Tiffany A., Wang, Shuzhen, Tiao, Ningyi, Kim, Yong-Wan, Liu, Juinn-Lin, Ramnarian, Deepti, Yuan, Ying, Garcia-Echevrria, Carlos, Maira, Sauveur-Michel, Yung, W.K. Alfred
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785365/
https://ncbi.nlm.nih.gov/pubmed/22065080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1558
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