The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia

Aberrant activation of the PI3K/Akt/mTOR pathway is a common feature of acute myeloid leukemia (AML) patients contributing to chemoresistance, disease progression and unfavourable outcome. Therefore, inhibition of this pathway may represent a potential therapeutic approach in AML. The aim of this st...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Allegretti, Matteo, Ricciardi, Maria Rosaria, Licchetta, Roberto, Mirabilii, Simone, Orecchioni, Stefania, Reggiani, Francesca, Talarico, Giovanna, Foà, Roberto, Bertolini, Francesco, Amadori, Sergio, Torrisi, Maria Rosaria, Tafuri, Agostino
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682184/
https://ncbi.nlm.nih.gov/pubmed/26674543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18137
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