JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

Activation of Janus Kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies(1-5). JAK2 is a non-receptor tyrosine kinase that regulates a number of cellular processes by inducing cytoplasmic signalling cascades. Here we show that JAK2 is pr...

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Autori principali: Dawson, Mark A., Bannister, Andrew J., Göttgens, Berthold, Foster, Samuel D., Bartke, Till, Green, Anthony R., Kouzarides, Tony
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785147/
https://ncbi.nlm.nih.gov/pubmed/19783980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08448
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