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JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Activation of Janus Kinase 2 (JAK2) by chromosomal translocations or point mutations is a frequent event in haematological malignancies(1-5). JAK2 is a non-receptor tyrosine kinase that regulates a number of cellular processes by inducing cytoplasmic signalling cascades. Here we show that JAK2 is pr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3785147/ https://ncbi.nlm.nih.gov/pubmed/19783980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08448 |
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