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The transcription factor Engrailed-2 guides retinal axons

Engrailed-2 (En-2), a homeodomain transcription factor, is expressed in a caudal-to-rostral gradient in the developing mid-brain, where it has an instructive role in patterning the optic tectum—the target of topographic retinal input(1,2). In addition to its well-known role in regulating gene expres...

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Main Authors: Brunet, Isabelle, Weinl, Christine, Piper, Michael, Trembleau, Alain, Volovitch, Michel, Harris, William, Prochiantz, Alain, Holt, Christine
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785142/
https://ncbi.nlm.nih.gov/pubmed/16267555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04110
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