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Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity
The aminopeptidase, ERAP1, trims peptides for MHC class I presentation, influencing the degree and specificity of CD8+ T cell responses. Single nucleotide polymorphisms (SNP) within the exons encoding ERAP1 are associated with autoimmune diseases and cervical carcinoma, but it is not known whether t...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3785127/ https://ncbi.nlm.nih.gov/pubmed/23733883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300598 |
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