Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosp...

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Autores principales: Shaw, Peter X., Hörkkö, Sohvi, Chang, Mi-Kyung, Curtiss, Linda K., Palinski, Wulf, Silverman, Gregg J., Witztum, Joseph L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2000
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC378505/
https://ncbi.nlm.nih.gov/pubmed/10862788
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