Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosp...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Shaw, Peter X., Hörkkö, Sohvi, Chang, Mi-Kyung, Curtiss, Linda K., Palinski, Wulf, Silverman, Gregg J., Witztum, Joseph L.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 2000
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC378505/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10862788/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8472
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