The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and β(2 )glycoprotein 1 (and other proteins)

Circulating autoantibodies to phospholipids (aPLs), such as cardiolipin (CL), are found in patients with antiphospholipid antibody syndrome (APS). We recently demonstrated that many aPLs bound to CL only after it had been oxidized (OxCL), but not to a reduced CL analogue that could not undergo oxida...

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Bibliographic Details
Main Authors: Hörkkö, Sohvi, Miller, Elizabeth, Branch, D. Ware, Palinski, Wulf, Witztum, Joseph L.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC23367/
https://ncbi.nlm.nih.gov/pubmed/9294215
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