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The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and β(2 )glycoprotein 1 (and other proteins)

Circulating autoantibodies to phospholipids (aPLs), such as cardiolipin (CL), are found in patients with antiphospholipid antibody syndrome (APS). We recently demonstrated that many aPLs bound to CL only after it had been oxidized (OxCL), but not to a reduced CL analogue that could not undergo oxida...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hörkkö, Sohvi, Miller, Elizabeth, Branch, D. Ware, Palinski, Wulf, Witztum, Joseph L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23367/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9294215/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.19.10356
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